Hi Bob, I’ve moved your topic to the “Ukulele Q&A” forum 🙂
It is definitely possible to play it ‘upside down’ and simply change the string order. So a symmetric ukulele might be your way to go and maybe some very small bridge and nut adjustments might be necessary. There are however also some dedicated ‘left-handed’ ukuleles available.
Hopefully this helped you a little bit 🙂